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This webinar will investigate the increasing mortality rates of liver disease in the UK associated with obesity and the excess consumption of alcohol. It will give an overview of non-alcoholic fatty liver disease (NAFLD), which is now the most common of liver disease affecting an estimated 25-30% of adults and 10% of children in the UK and worldwide. Both NAFLD and alcohol-related fatty liver can progress to severe liver disease including fibrosis, cirrhosis and hepatocellular carcinoma. The roles of genetics, obesity and dietary patterns in the development and progression of liver disease will be discussed. In the context of controversy around dietary guidelines recommending low-fat/high-carbohydrate diets, the topical questions of, if and how dietary fats and carbohydrates, including simple sugars, may differentially influence NAFLD pathogenesis will be addressed. The results of cross-sectional studies of dietary habits in patients with NAFLD and intervention trials that have examined the effects of altering dietary macronutrients will be reviewed.